Montiel G, Horn T, Vafa R, Solera A, Hollmann W, Predel H G, Brinkmann C
Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
University of Costa Rica, San Pedro, Costa Rica.
Wien Klin Wochenschr. 2016 Mar;128(5-6):193-7. doi: 10.1007/s00508-015-0881-9. Epub 2015 Nov 6.
Numerous studies with male amateur runners have determined negative changes in their cardiac function/of their myocard following long endurance loads. This study aims to examine such potential changes in women, specifically, after running a marathon.
A total of 18 female amateur runners (39.5 ± 10.5 years) were examined before (T1), immediately after (T2) and 24 h post-marathon (T3). An echocardiography was performed using Tissue Doppler (TD) imaging. In addition, the concentration of cardiac troponin T (cTnT) and the activity of the myocardial muscle creatine kinase (CK-MB) were determined at T1 and T2.
The echocardiographic parameters revealed impairment of the diastolic function, without, however, documenting a diastolic dysfunction (in accordance with the classification of Nagueh (J Am Soc Echocardiogr, 22:107-33, 2009)). The ratio of blood flow velocity through the mitral valve during early versus late diastole (MV E/A ratio), for example, decreased. The values measured at T3 were similar to those measured at T1. The ratio of early transmitral diastolic filling velocity and of the transmitral diastolic filling velocity by TD imaging (MV E/E') did not indicate any change from T1 to T2, but a significant increase at T3 (in comparison with T1). The systolic function (measured by the left ventricular ejection fraction) did not change significantly. The cTnT concentration and CK-MB activity were significantly higher in T2 than in T1.
The data collected does not provide any solid evidence of pathological changes in the cardiac function of female amateur runners post-marathon, although the lab values indicate a strongly increased myocardial stimulation.
大量针对男性业余跑步者的研究已经确定，在承受长时间耐力负荷后，他们的心脏功能/心肌会出现负面变化。本研究旨在检验女性在跑完马拉松后是否会出现此类潜在变化。
共有18名女性业余跑步者（39.5±10.5岁）在马拉松前（T1）、结束后即刻（T2）以及结束后24小时（T3）接受检查。使用组织多普勒（TD）成像进行超声心动图检查。此外，在T1和T2时测定心肌肌钙蛋白T（cTnT）的浓度以及心肌肌酸激酶（CK-MB）的活性。
超声心动图参数显示舒张功能受损，但未记录到舒张功能障碍（根据纳古埃的分类标准（《美国超声心动图学会杂志》，22:107 - 33, 2009年））。例如，舒张早期与晚期通过二尖瓣的血流速度比值（MV E/A比值）降低。T3时测得的值与T1时相似。舒张早期二尖瓣血流速度与TD成像测得的二尖瓣舒张期血流速度之比（MV E/E'）从T1到T2未显示任何变化，但在T3时显著增加（与T1相比）。收缩功能（通过左心室射血分数测量）没有显著变化。T2时cTnT浓度和CK-MB活性显著高于T1。
尽管实验室值表明心肌刺激显著增加，但所收集的数据并未提供任何确凿证据证明女性业余跑步者在跑完马拉松后心脏功能发生了病理变化。
