Gkioka Eliona, Msaouel Pavlos, Philippou Anastassios, Vlaghogiannis Nikolaos I, Vogkou Christiana T, Margiolis Argyris, Koutsilieris Michael
Department of Experimental Physiology, Medical School, National & Kapodistrian University of Athens, Athens, Greece.
Albert Einstein College of Medicine, Jacobi Medical Center, Bronx, NY, U.S.A.
In Vivo. 2015 Nov-Dec;29(6):637-49.
A growing body of evidence suggests the association of the IGF-I bio-regulatory system with leiomyoma occurrence and growth. The complex interplay between IGF-I/IGF-IR and hormonal and other growth factors is, thus, now receiving significant attention. Elucidation of the molecular mechanisms driving the disease may allow for development of novel targeted-therapeutic strategies for the treatment of leiomyomas. Herein, we provide a concise update and overview of the function and regulation of IGF-I and its role in leiomyoma growth.
越来越多的证据表明胰岛素样生长因子-I（IGF-I）生物调节系统与平滑肌瘤的发生和生长有关。因此，IGF-I/IGF-IR与激素及其他生长因子之间复杂的相互作用现在受到了广泛关注。阐明导致该疾病的分子机制可能有助于开发治疗平滑肌瘤的新型靶向治疗策略。在此，我们简要介绍并概述了IGF-I的功能、调节及其在平滑肌瘤生长中的作用。
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