病毒免疫中的载脂蛋白B mRNA编辑酶催化多肽样蛋白3（APOBEC3）家族蛋白
APOBEC3 Proteins in Viral Immunity.
作者信息
Stavrou Spyridon, Ross Susan R
机构信息
Department of Microbiology, Abramson Cancer Center, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6142.
Department of Microbiology, Abramson Cancer Center, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6142
出版信息
J Immunol. 2015 Nov 15;195(10):4565-70. doi: 10.4049/jimmunol.1501504.
Abstract
Apolipoprotein B editing complex 3 family members are cytidine deaminases that play important roles in intrinsic responses to infection by retroviruses and have been implicated in the control of other viruses, such as parvoviruses, herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons. Although their direct effect on modification of viral DNA has been clearly demonstrated, whether they play additional roles in innate and adaptive immunity to viruses is less clear. We review the data regarding the various steps in the innate and adaptive immune response to virus infection in which apolipoprotein B editing complex 3 proteins have been implicated.
摘要
载脂蛋白B编辑复合体3家族成员是胞苷脱氨酶，在对逆转录病毒感染的固有反应中发挥重要作用，并且与对其他病毒（如细小病毒、疱疹病毒、乳头瘤病毒、乙型肝炎病毒和逆转座子）的控制有关。虽然它们对病毒DNA修饰的直接作用已得到明确证实，但它们在病毒的固有免疫和适应性免疫中是否发挥其他作用尚不清楚。我们综述了有关载脂蛋白B编辑复合体3蛋白参与病毒感染固有免疫和适应性免疫反应各个步骤的数据。
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