联合给药系统在鸡尾酒化疗方面的最新进展。
Recent advances of cocktail chemotherapy by combination drug delivery systems.
作者信息
Hu Quanyin, Sun Wujin, Wang Chao, Gu Zhen
机构信息
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
出版信息
Adv Drug Deliv Rev. 2016 Mar 1;98:19-34. doi: 10.1016/j.addr.2015.10.022. Epub 2015 Nov 6.
Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. However, the traditional cocktail administration of combination regimens often suffers from varying pharmacokinetics among different drugs. The emergence of nanotechnology offers an unparalleled opportunity for developing advanced combination drug delivery strategies with the ability to encapsulate various drugs simultaneously and unify the pharmacokinetics of each drug. This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers. The mechanisms underlying combination chemotherapy, including the synergistic, additive and potentiation effects, are also discussed with typical examples. We further highlight the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. Clinical outlook and challenges are also discussed in the end.
联合化疗在临床上被广泛用于增强癌症治疗效果。然而，传统联合治疗方案的鸡尾酒式给药方式常常存在不同药物之间药代动力学各异的问题。纳米技术的出现为开发先进的联合药物递送策略提供了前所未有的机遇，这种策略能够同时封装多种药物并统一每种药物的药代动力学。本综述考察了使用纳米载体进行多种小分子化疗药物联合递送的最新进展。还通过典型实例讨论了联合化疗的潜在机制，包括协同、相加和增强作用。我们进一步强调了序贯和位点特异性共递送策略，这些策略为可编程联合药物递送系统的开发提供了新的指导方针。最后还讨论了临床前景和挑战。
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