University POLITEHNICA of Bucharest, RO-011061 Bucharest, Romania.
National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania.
Int J Pharm. 2016 Aug 30;510(2):449-56. doi: 10.1016/j.ijpharm.2015.10.083. Epub 2015 Nov 4.
Pulsed laser deposition (PLD) method was used to obtain biovitroceramic thin film coatings on titanium substrates. The composition of the targets was selected from SiO2-CaO-P2O5-(CaF2) systems and the corresponding masses were prepared using the sol-gel method. The depositions were performed in oxygen atmosphere (100mTorr), while the substrates were heated at 400°C. The PLD deposited films were analysed through different experimental techniques: X-ray diffraction, scanning (SEM, EDX) and transmission (HRTEM, SAED) electron microscopy and infra-red spectroscopy coupled with optical microscopy. They were also biologically tested by in vitro cell culture and the contact angle was determined. The bioevaluation results indicate a high biocompatibilty of the obtained materials, demonstrating their potential use for biomedical applications.
脉冲激光沉积（PLD）方法被用于在钛基底上获得生物玻璃陶瓷薄膜涂层。靶材的组成选自 SiO2-CaO-P2O5-(CaF2) 体系，相应的质量通过溶胶-凝胶法制备。沉积在氧气氛围（100mTorr）中进行，同时基底加热至 400°C。通过不同的实验技术分析 PLD 沉积的薄膜：X 射线衍射、扫描（SEM、EDX）和透射（HRTEM、SAED）电子显微镜以及与光学显微镜耦合的红外光谱。还通过体外细胞培养进行生物测试，并确定接触角。生物评价结果表明所获得材料具有较高的生物相容性，证明它们在生物医学应用中有潜在的用途。
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