Santana Patricia T, Martel Jan, Lai Hsin-Chih, Perfettini Jean-Luc, Kanellopoulos Jean M, Young John D, Coutinho-Silva Robson, Ojcius David M
Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA; Laboratory of Immunophysiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Center for Molecular and Clinical Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; Laboratory of Nanomaterials, Chang Gung University, Taoyuan, Taiwan, ROC.
Microbes Infect. 2016 Feb;18(2):93-101. doi: 10.1016/j.micinf.2015.10.007. Epub 2015 Nov 10.
Inflammasomes are intracellular protein complexes that sense microbial components and damage of infected cells. Following activation by molecules released by pathogens or injured cells, inflammasomes activate caspase-1, allowing secretion of the pro-inflammatory cytokines IL-1β and IL-18 from innate immune cells. Inflammasomes are also expressed in epithelial cells, where their function has attracted less attention. Nonetheless, depending on the tissue, epithelial inflammasomes can mediate inflammation, wound healing, and pain sensitivity. We review here recent findings on inflammasomes found in epithelial tissues, highlighting the importance of these protein complexes in the response of epithelial tissues to microbial infections.
炎性小体是一种细胞内蛋白质复合物，可感知微生物成分以及受感染细胞的损伤。在被病原体或受损细胞释放的分子激活后，炎性小体激活半胱天冬酶-1，从而使先天性免疫细胞分泌促炎细胞因子白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）。炎性小体也在上皮细胞中表达，但其功能较少受到关注。尽管如此，根据组织不同，上皮炎性小体可介导炎症、伤口愈合和疼痛敏感性。我们在此综述上皮组织中炎性小体的最新研究发现，强调这些蛋白质复合物在上皮组织对微生物感染反应中的重要性。
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