Guo Qian, Zha Xicao, Li Chun, Jia Yuan, Zhu Lei, Guo Jianping, Su Yin
Department of Rheumatology and Immunology, Peking University People's Hospital, 11 South Xizhimen Street, Beijing, 100044, China.
Department of Traditional Chinese Medicine, North Branch of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830054, China.
Clin Rheumatol. 2016 Jan;35(1):73-9. doi: 10.1007/s10067-015-3108-6. Epub 2015 Nov 7.
Calprotectin is a calcium-binding cytosolic protein, mainly expressed in immune cells, such as neutrophils, monocytes, and macrophages. Our study aimed to evaluate the diagnostic value of calprotectin for adult-onset Still's disease (AOSD), by comparing serum calprotectin concentrations in patients with AOSD (n = 46), rheumatoid arthritis (RA, n = 34), primary Sjögren syndrome (pSS, n = 40), systemic lupus erythematosus (SLE, n = 39), osteoarthritis (OA, n = 20), and healthy controls (HCs, n = 49). Calprotectin concentrations were significantly higher in patients with AOSD (55.26 ± 18.00 ng/ml), compared to patients with RA (39.17 ± 18.90 ng/ml), pSS (35.31 ± 19.47 ng/ml), SLE (32.21 ± 25.01 ng/ml), OA (19.24 ± 10.67 ng/ml), and HCs (8.46 ± 5.17 ng/ml). All the differences were highly significant (p < 0.001). Using receiver-operating characteristic curve, the cut-off value of calprotectin was defined as 45.488 ng/ml, and its sensitivity and specificity for AOSD diagnosis were 63.0 and 80.1%, respectively. The positive rate of calprotectin was significantly higher in AOSD cases compared to patients with other diseases and healthy controls (p < 0.001). Serum calprotectin was positively correlated with ferritin (r = 0.294, p < 0.05), and concentration of hemoglobin was significantly lower in calprotectin-positive patients compared to negative patients in AOSD (103.49 ± 20.21 g/l vs 115.71 ± 15.59 g/l, t = -2.142, p = 0.038). These findings suggest that serum calprotectin may serve as a promising marker for the diagnosis of AOSD and monitor disease activity to a certain extent.
钙卫蛋白是一种结合钙的胞质蛋白，主要在免疫细胞中表达，如中性粒细胞、单核细胞和巨噬细胞。我们的研究旨在通过比较成人斯蒂尔病（AOSD，n = 46）、类风湿关节炎（RA，n = 34）、原发性干燥综合征（pSS，n = 40）、系统性红斑狼疮（SLE，n = 39）、骨关节炎（OA，n = 20）患者及健康对照者（HCs，n = 49）的血清钙卫蛋白浓度，评估钙卫蛋白对成人斯蒂尔病的诊断价值。与RA（39.17±18.90 ng/ml）、pSS（35.31±19.47 ng/ml）、SLE（32.21±25.01 ng/ml）、OA（19.24±10.67 ng/ml）患者及HCs（8.46±5.17 ng/ml）相比，AOSD患者的钙卫蛋白浓度显著更高（55.26±18.00 ng/ml）。所有差异均具有高度显著性（p < 0.001）。采用受试者工作特征曲线，将钙卫蛋白的截断值定义为45.488 ng/ml，其对AOSD诊断的敏感性和特异性分别为63.0%和80.1%。与其他疾病患者及健康对照者相比，AOSD患者的钙卫蛋白阳性率显著更高（p < 0.001）。血清钙卫蛋白与铁蛋白呈正相关（r = 0.294，p < 0.05），在AOSD中，钙卫蛋白阳性患者的血红蛋白浓度显著低于阴性患者（103.49±20.21 g/l对115.71±15.59 g/l，t = -2.142，p = 0.038）。这些发现表明，血清钙卫蛋白可能是AOSD诊断的一个有前景的标志物，并在一定程度上可监测疾病活动。
