Navarro-Martínez Rut, Fernández-Garrido Julio, Buigues Cristina, Martinez-Martinez Mary, Cantero-Díaz Liliana, Santamaría-Carrillo Yolanda, Serra-Catalá Nuria, Peris Carlos, Cauli Omar
Department of Medical Nursing, Faculty of Nursing, University of Valencia, 46010 Valencia, Spain.
Centro municipal para personas mayores "Arniches", 46014 Valencia, Spain.
Appl Nurs Res. 2016 May;30:e10-4. doi: 10.1016/j.apnr.2015.10.002. Epub 2015 Oct 23.
Serum vitamin D deficiency has been associated with frailty in people aged 65 and over, however its relationship with functional impairment has not been investigated in octogenerian (aged 80-90 years) institutionalized women.
We assessed functional impairment in this latter group by measuring frailty syndrome and other geriatric and psychological assessment scales: the Tinetti gait and balance index to determine the risk for falls, the Barthel index to measure the basic activities of daily living, the Lawton index for instrumental activities, the mini-mental score examination test for cognitive impairment, the Yesavage scale for geriatric depression, and the Norton scale for the risk of ulceration.
Frail individuals had significantly reduced serum vitamin D concentrations (measured as total 25-hydroxyvitamin D; 25(OH)D) compared to robust individuals, but reduced 25(OH)D concentration did not significantly correlate with frailty syndrome severity, and mean 25(OH)D concentrations were within the recommended levels in all groups. The 25(OH)D concentration did not correlate with any of the blood analytical parameters measured and with the geriatric assessment scales used, suggesting a selective relationship with frailty.
These results highlight the need to individualize treatment such as vitamin D supplementation in order to treat frailty syndrome.
血清维生素D缺乏与65岁及以上人群的虚弱有关，然而，其与80至90岁机构养老女性功能损害之间的关系尚未得到研究。
我们通过测量虚弱综合征以及其他老年和心理评估量表，对后一组人群的功能损害进行评估：用Tinetti步态和平衡指数确定跌倒风险，用Barthel指数测量日常生活基本活动，用Lawton指数评估工具性活动，用简易精神状态检查表检测认知障碍，用Yesavage量表评估老年抑郁，用诺顿量表评估溃疡风险。
与身体强壮的个体相比，虚弱个体的血清维生素D浓度（以总25-羟基维生素D；25(OH)D衡量）显著降低，但25(OH)D浓度降低与虚弱综合征严重程度无显著相关性，且所有组的25(OH)D平均浓度均在推荐水平范围内。25(OH)D浓度与所测量的任何血液分析参数以及所使用的老年评估量表均无相关性，表明其与虚弱存在选择性关系。
这些结果凸显了个性化治疗（如补充维生素D）以治疗虚弱综合征的必要性。
