Division of Geriatric Research, Institute of Population Health Sciences, National Health Research Institutes, No. 17 Xu-Zhou Road, Taipei, Taiwan.
Arch Gerontol Geriatr. 2010 Feb;50 Suppl 1:S17-21. doi: 10.1016/S0167-4943(10)70006-6.
This study explored the association between vitamin D insufficiency and frailty syndrome defined by the Fried Frailty Index (FFI) and the Edmonton Frail Scale (EFS) in a northern Taiwan community. Data of 215 subjects participating in an integrated interventional trial involving community-dwelling older adults with a high frailty risk were analyzed. Subjects were first screened by telephone interview and then evaluated at a local hospital with questionnaires, physical performance tests, and serum 25(OH)D measurements. Of the 215 participants, 31% had 25(OH)D insufficiency (< 20 ng/ml). Frail subjects based on the FFI were older, had lower Mini-Mental Status Exam (MMSE) scores, Barthel Index (BI) scores, and 25(OH)D levels. Using the EFS, frailer cases were more likely to be female, have less education, higher comorbid conditions, lower MMSE scores, lower Barthel Index scores, and lower 25(OH)D levels. The associations between insufficient 25(OH)D status and both frailty scales were significant. After adjustment of variables, the odds ratio of 25(OH)D insufficiency was 10.74 (95% CI 2.60-44.31) for frail versus robust individuals. The prevalence of vitamin D insufficiency was high in this population. There was a strong association between vitamin D insufficiency and the FFI. Vitamin D measurements and supplements are suggested for high-risk older people.
本研究旨在探讨台湾北部社区中维生素 D 不足与衰弱综合征（通过 Fried 衰弱指数 [FFI] 和埃德蒙顿衰弱量表 [EFS] 定义）之间的关联。对参与涉及高衰弱风险的社区居住老年人的综合干预性试验的 215 名受试者的数据进行了分析。首先通过电话访谈对受试者进行筛查，然后在当地医院进行问卷调查、身体机能测试和血清 25（OH）D 测量进行评估。在 215 名参与者中，31%存在 25（OH）D 不足（<20ng/ml）。基于 FFI 的衰弱受试者年龄较大，认知状态简易量表（MMSE）评分、巴氏量表（BI）评分和 25（OH）D 水平较低。根据 EFS，更虚弱的病例更可能是女性，受教育程度较低，合并症较多，认知状态简易量表（MMSE）评分、巴氏量表（BI）评分和 25（OH）D 水平较低。25（OH）D 不足状态与两种衰弱量表之间存在显著关联。调整变量后，25（OH）D 不足的优势比为 10.74（95%CI 2.60-44.31），即衰弱与健壮个体相比。该人群中维生素 D 不足的发生率较高。维生素 D 不足与 FFI 之间存在很强的关联。建议高危老年人进行维生素 D 测量和补充。
