Soares-da-Silva Patrício, Cabral José Miguel, Magalhães Diogo, Fraga Sónia, Magro Fernando
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.
Exp Physiol. 2016 Apr;101(4):459-64. doi: 10.1113/EP085284. Epub 2015 Dec 14.
What is the topic of this review? The present work reviews the roles of renal and intestinal dopamine and 5-HT in the maintenance of fluid and electrolyte homeostasis. The role of inflammatory agents at the intestinal level that affect fluid and electrolyte homeostasis is also addressed. What advances does it highlight? General mechanisms of epithelial cell ion transport in the gastrointestinal tract and kidney share considerable similarities, particularly with regard to basolateral Na(+) ,K(+-) ATPase as a driving force for the movement of numerous substrates across the cell membrane. The physiological importance of the renal actions of monoamines (dopamine, noradrenaline and 5-HT) mainly depends on the sources of the amines in the kidney and on their availability to activate the amine-specific receptors. Dopamine and 5-HT are also relatively abundant in the mucosal cell layer of the intestine, and recent evidence suggests their physiological relevance in regulating electrolyte transport. The gastrointestinal tract can be an important site for the loss of water and electrolytes, in the presence of intestinal inflammation. General mechanisms of epithelial cell ion transport in the gastrointestinal tract and kidney share considerable similarities with regard to basolateral Na(+) ,K(+) -ATPase as a driving force for the movement of numerous substrates across the cell membrane. The present work reviews the roles of renal and intestinal dopamine and 5-HT in the maintenance of fluid and electrolyte homeostasis. The role of inflammatory agents at the intestinal level that affect fluid and electrolyte homeostasis is also addressed.
这篇综述的主题是什么？当前的研究综述了肾脏和肠道中的多巴胺及5-羟色胺在维持体液和电解质平衡方面的作用。还探讨了影响体液和电解质平衡的肠道炎症因子的作用。它突出了哪些进展？胃肠道和肾脏中上皮细胞离子转运的一般机制有相当多的相似之处，特别是在基底外侧钠钾ATP酶作为众多底物跨细胞膜转运驱动力方面。单胺类物质（多巴胺、去甲肾上腺素和5-羟色胺）在肾脏中的生理重要性主要取决于肾脏中胺类物质的来源及其激活胺类特异性受体的能力。多巴胺和5-羟色胺在肠道黏膜细胞层中也相对丰富，最近的证据表明它们在调节电解质转运方面具有生理相关性。在肠道炎症存在的情况下，胃肠道可能是水和电解质丢失的重要部位。胃肠道和肾脏中上皮细胞离子转运的一般机制在基底外侧钠钾ATP酶作为众多底物跨细胞膜转运驱动力方面有相当多的相似之处。当前的研究综述了肾脏和肠道中的多巴胺及5-羟色胺在维持体液和电解质平衡方面的作用。还探讨了影响体液和电解质平衡的肠道炎症因子的作用。
