Qaddumi Waleed N, Jose Pedro A
Columbian College of Arts & Sciences, The George Washington University, Washington, DC 20052, USA.
Department of Medicine and Department of Physiology/Pharmacology, Division of Renal Diseases & Hypertension, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA.
Biomedicines. 2021 Feb 1;9(2):139. doi: 10.3390/biomedicines9020139.
The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension. The five dopamine receptor subtypes (DR-DR) have important roles in the regulation of blood pressure through several mechanisms, such as inhibition of oxidative stress. Dopamine receptors, including those expressed in the kidney, reduce oxidative stress by inhibiting the expression or action of receptors that increase oxidative stress. In addition, dopamine receptors stimulate the expression or action of receptors that decrease oxidative stress. This article examines the importance and relationship between the renal dopaminergic system and oxidative stress in the regulation of renal sodium handling and blood pressure. It discusses the current information on renal dopamine receptor-mediated antioxidative network, which includes the production of reactive oxygen species and abnormalities of renal dopamine receptors. Recognizing the mechanisms by which renal dopamine receptors regulate oxidative stress and their degree of influence on the pathogenesis of hypertension would further advance the understanding of the pathophysiology of hypertension.
肾脏在血压的长期调节中起着关键作用。氧化应激是导致高血压的众多因素之一。五种多巴胺受体亚型（DR - DR）通过多种机制在血压调节中发挥重要作用，如抑制氧化应激。多巴胺受体，包括在肾脏中表达的那些，通过抑制增加氧化应激的受体的表达或作用来降低氧化应激。此外，多巴胺受体刺激降低氧化应激的受体的表达或作用。本文探讨了肾多巴胺能系统与氧化应激在肾钠处理和血压调节中的重要性及关系。讨论了关于肾多巴胺受体介导的抗氧化网络的当前信息，其中包括活性氧的产生和肾多巴胺受体的异常。认识到肾多巴胺受体调节氧化应激的机制及其对高血压发病机制的影响程度，将进一步推进对高血压病理生理学的理解。
