Griffith D J, Mackintosh C L, Inverarity D
Regional Infectious Diseases Unit,Western General Hospital,Edinburgh,UK.
Department of Microbiology,Royal Infirmary of Edinburgh,UK.
Epidemiol Infect. 2016 Apr;144(6):1257-66. doi: 10.1017/S095026881500271X. Epub 2015 Nov 9.
Injecting drug use is often associated with deep-seated infection. In Lothian in Scotland there has been a recent increase in the use of injected new psychoactive substances (NPS). Patients who have injected NPS have presented with Staphylococcus aureus bacteraemia (SAB) with life-threatening complications. We describe a unique case-series of 14 episodes of SAB in ten patients. Users of injected NPS had a significantly higher incidence of endocarditis and cavitating pulmonary lesions (P < 0·05) compared to those who inject only opiates. Cases of SAB in people who inject NPS have contributed to a significant rise in the overall incidence of SAB in people who inject drugs (P < 0·05) which has in turn impacted on the ability of Lothian to meet national targets for reducing the incidence of SAB.
注射吸毒往往与深部感染有关。在苏格兰的洛锡安，近期注射新型精神活性物质（NPS）的情况有所增加。注射NPS的患者出现了金黄色葡萄球菌菌血症（SAB）并伴有危及生命的并发症。我们描述了一个独特的病例系列，涉及10名患者的14次SAB发作。与仅注射阿片类药物的使用者相比，注射NPS的使用者患心内膜炎和肺空洞性病变的发生率显著更高（P < 0·05）。注射NPS人群中的SAB病例导致了注射毒品人群中SAB总体发病率的显著上升（P < 0·05），这反过来又影响了洛锡安实现降低SAB发病率国家目标的能力。
