Lines Gregory, Hunter Paul, Bleything Sarah
J Health Care Poor Underserved. 2015 Nov;26(4):1428-39. doi: 10.1353/hpu.2015.0126.
Prophylactic treatment of latent tuberculosis infection (LTBI) is necessary for controlling TB in low-incidence settings. However, treatment is often limited by poor completion rates.
At a community health center serving low-income Hispanics, treatment completion among patients accepting 12 weekly doses of isoniazid (INH) plus rifapentine (RPT) administered as directly observed therapy (DOT) was compared with that among patients accepting nine months of daily self-administered INH during 2012 and 2013 (n=139).
Among patients who agreed to treatment, INH-RPT combination therapy was associated with higher completion rates (OR 3.06; 95% CI, 1.23-7.62; p=.016) when compared to INH only. Overall completion rates were 77.8% (35/45) for INH-RPT combination therapy and 52.1% (49/94) for INH monotherapy.
High completion rates for LTBI treatment can be achieved at a community health center using INH-RPT administered via DOT. Greater success treating with INH-RPT may be attributed to DOT strategy and a shorter treatment regimen.
在低发病率地区，预防性治疗潜伏性结核感染（LTBI）对于控制结核病是必要的。然而，治疗常常受到低完成率的限制。
在一家为低收入西班牙裔人群服务的社区卫生中心，比较了2012年和2013年接受12周每周一次异烟肼（INH）加利福喷汀（RPT）直接观察治疗（DOT）的患者与接受9个月每日自我服用INH的患者的治疗完成情况（n = 139）。
在同意治疗的患者中，与仅使用INH相比，INH-RPT联合治疗的完成率更高（比值比3.06；95%置信区间，1.23 - 7.62；p = 0.016）。INH-RPT联合治疗的总体完成率为77.8%（35/45），INH单药治疗为52.1%（49/94）。
在社区卫生中心通过DOT使用INH-RPT可实现较高的LTBI治疗完成率。使用INH-RPT治疗取得更大成功可能归因于DOT策略和更短的治疗方案。
