Sato Jun, Ohuchi Manabu, Wada Mayumi, Ohga Noritaka, Asaka Takuya, Yoshikawa Kazuhito, Miyakoshi Masaaki, Hata Hironobu, Satoh Akira, Kitagawa Yoshimasa
Lecturer, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
Clinical Fellow, Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):751-60.e2. doi: 10.1016/j.oooo.2015.08.016. Epub 2015 Sep 5.
Sequential postoperative salivary interleukin-6 (IL-6) concentrations were examined in patients with oral squamous cell carcinoma (OSCC) who had early or late locoregional recurrences or those who did not.
Twenty-seven consecutive patients with OSCC were originally included in the study. All patients underwent radical surgery. Four saliva samples were collected before (periods I and II) and after (periods III and IV) surgery, and IL-6 concentrations were measured.
Although postoperative (period III: at the time of discharge) salivary IL-6 level was significantly higher in patients with early locoregional recurrence (P = .02) than in those without, no such relationships were observed for preoperative IL-6 concentrations (periods I and II). Postoperative (period IV: 24 months after surgery) IL-6 level was significantly higher in patients with late locoregional recurrence (P = .03) than in those without, but no such relationships were observed for IL-6 concentrations in periods I, II, and III.
Sequential postoperative salivary IL-6 concentration may be a useful marker for diagnosis of early and late locoregional recurrence in OSCC.
对出现早期或晚期局部区域复发以及未出现复发的口腔鳞状细胞癌（OSCC）患者术后唾液白细胞介素-6（IL-6）浓度进行序贯检测。
最初有27例连续的OSCC患者纳入本研究。所有患者均接受根治性手术。在手术前（阶段I和II）和手术后（阶段III和IV）采集四份唾液样本，并检测IL-6浓度。
尽管早期局部区域复发患者术后（阶段III：出院时）唾液IL-6水平显著高于未复发患者（P = 0.02），但术前IL-6浓度（阶段I和II）未观察到此类关系。晚期局部区域复发患者术后（阶段IV：术后24个月）IL-6水平显著高于未复发患者（P = 0.03），但在阶段I、II和III的IL-6浓度未观察到此类关系。
术后唾液IL-6浓度序贯检测可能是诊断OSCC早期和晚期局部区域复发的有用标志物。
