Institute of Anatomy, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.
Department of Stomatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 12801 Prague, Czech Republic.
Int J Mol Sci. 2021 Oct 13;22(20):11027. doi: 10.3390/ijms222011027.
Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.
白细胞介素 6（IL-6）是一种具有高度活性的细胞因子，参与多种生物学过程。此前有研究报道称，IL-6 在炎症、自身免疫和精神疾病、衰老和各种类型的癌症中发挥独特作用。此外，人们已经了解到，IL-6 及其信号通路是协调肿瘤微环境的重要参与者。因此，它们似乎是抗肿瘤治疗的潜在靶点。本文旨在阐明 IL-6 在肿瘤生态系统中的作用，并综述头颈部癌症的可能治疗方法。
