Badawi Maha, Almazrooa Soulafa, Azher Fatima, Alsayes Fatin
Assistant Professor, Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Assistant Professor, Department of Oral Diagnostic Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Dec;120(6):e232-4. doi: 10.1016/j.oooo.2015.09.006. Epub 2015 Sep 16.
Hydroxyurea is an antimetabolite that is widely used in the treatment of many benign and malignant conditions. This drug is usually well tolerated but has a number of side effects that vary in incidence. In cases of clinically significant adverse events, hydroxyurea is usually discontinued either temporarily or permanently, depending on treatment need versus harm caused by side effects. Here, we report a case of oral ulceration associated with hydroxyurea treatment in a patient who had chronic myelogenous leukemia. The patient rapidly developed an oral ulcer 12 days after administration of the drug. Hydroxyurea was discontinued, and the oral lesion appreciably decreased in size and severity. Physicians and dentists should be aware of the association between hydroxyurea and oral lesions.
羟基脲是一种抗代谢药物，广泛用于治疗多种良性和恶性疾病。这种药物通常耐受性良好，但有一些发生率各不相同的副作用。在发生具有临床意义的不良事件时，根据治疗需求与副作用造成的损害情况，羟基脲通常会暂时或永久停用。在此，我们报告一例慢性粒细胞白血病患者在接受羟基脲治疗后出现口腔溃疡的病例。该患者在用药12天后迅速出现口腔溃疡。停用羟基脲后，口腔病变的大小和严重程度明显减轻。医生和牙医应注意羟基脲与口腔病变之间的关联。
