Norhaya M R, Cheong S K, Ainoon O, Hamidah N H
Haematology Unit, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Singapore Med J. 1997 Jul;38(7):283-4.
Five patients treated with hydroxyurea for various haematological malignancies developed multiple painful oral ulcers. Their neutrophil counts were either normal or elevated. The ulcers disappeared with cessation of hydroxyurea. Oral ulcers recurred when hydroxyurea was resumed in one of the patients. As the patients were unable to tolerate this painful side effect, hydroxyurea had to be discontinued. Appearance of painful oral ulceration seems to be independent of dosing rate or total cumulative dose of hydroxyurea.
五名接受羟基脲治疗各种血液系统恶性肿瘤的患者出现了多处疼痛性口腔溃疡。他们的中性粒细胞计数正常或升高。停用羟基脲后溃疡消失。其中一名患者重新使用羟基脲时口腔溃疡复发。由于患者无法耐受这种疼痛的副作用，不得不停用羟基脲。疼痛性口腔溃疡的出现似乎与羟基脲的给药速率或总累积剂量无关。
