Kim Kwoneel, Lee Kibaick, Bang Hyoeun, Kim Jeong Yeon, Choi Jung Kyoon
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
Methods. 2016 Jun 1;102:50-6. doi: 10.1016/j.ymeth.2015.10.020. Epub 2015 Nov 5.
As a final function of various epigenetic mechanisms, chromatin regulation is a transcription control process that especially demonstrates active interaction with genetic elements. Thus, chromatin structure has become a principal focus in recent genomics researches that strive to characterize regulatory functions of DNA variants related to diseases or other traits. Although researchers have been focusing on DNA methylation when studying monozygotic (MZ) twins, a great model in epigenetics research, interactions between genetics and epigenetics in chromatin level are expected to be an imperative research trend in the future. In this review, we discuss how the genome, epigenome, and transcriptome of MZ twins can be studied in an integrative manner from this perspective.
作为各种表观遗传机制的最终功能，染色质调控是一种转录控制过程，尤其表现出与遗传元件的积极相互作用。因此，染色质结构已成为近期基因组学研究的主要焦点，这些研究致力于表征与疾病或其他性状相关的DNA变异的调控功能。尽管研究人员在研究同卵双胞胎（MZ）这一表观遗传学研究的优秀模型时一直聚焦于DNA甲基化，但染色质水平上遗传学与表观遗传学之间的相互作用有望成为未来必不可少的研究趋势。在这篇综述中，我们将从这一角度探讨如何以综合的方式研究MZ双胞胎的基因组、表观基因组和转录组。
