Ao Qilin, Su Wenjing, Guo Shuang, Cai Lei, Huang Lei
Institute of Pathology of Tongji Hospital and Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Department of Pathology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.
Sci Rep. 2015 Nov 9;5:16396. doi: 10.1038/srep16396.
Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.
缺氧诱导因子1α（HIF-1α）与卵巢癌的化疗耐药密切相关。尽管有报道称HIF-1α可受类泛素化特异性蛋白酶1（SENP1）调控，但SENP1对HIF-1α的影响仍存在争议。在本研究中，我们发现SENP1通过去SUMO化作用正向调控HIF-1α的表达，并削弱了缺氧卵巢癌细胞对顺铂的敏感性。这些结果表明，SENP1是HIF-1α的正向调节因子，在卵巢癌化疗中起负性作用。
