SENP1通过上调HIF-1α使缺氧的卵巢癌细胞对顺铂脱敏。

SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α.

作者信息

Ao Qilin, Su Wenjing, Guo Shuang, Cai Lei, Huang Lei

机构信息

Institute of Pathology of Tongji Hospital and Department of Pathology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Department of Pathology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China.

出版信息

Sci Rep. 2015 Nov 9;5:16396. doi: 10.1038/srep16396.

Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.