Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Oxid Med Cell Longev. 2021 Oct 7;2021:8388258. doi: 10.1155/2021/8388258. eCollection 2021.
Oxidative stress (OS) arises when the body is subjected to harmful endogenous or exogenous factors that overwhelm the antioxidant system. There is increasing evidence that OS is involved in a number of diseases, including ovarian cancer (OC). OC is the most lethal gynecological malignancy, and risk factors include genetic factors, age, infertility, nulliparity, microbial infections, obesity, smoking, etc. OS can promote the proliferation, metastasis, and therapy resistance of OC, while high levels of OS have cytotoxic effects and induce apoptosis in OC cells. This review focuses on the relationship between OS and the development of OC from four aspects: genetic alterations, signaling pathways, transcription factors, and the tumor microenvironment. Furthermore, strategies to target aberrant OS in OC are summarized and discussed, with a view to providing new ideas for clinical treatment.
氧化应激（OS）是指当身体受到有害的内源性或外源性因素的侵袭，超过抗氧化系统的承受能力时产生的一种状态。越来越多的证据表明，OS 与许多疾病有关，包括卵巢癌（OC）。OC 是最致命的妇科恶性肿瘤，其危险因素包括遗传因素、年龄、不孕、未婚、微生物感染、肥胖、吸烟等。OS 可以促进 OC 的增殖、转移和治疗耐药性，而高水平的 OS 具有细胞毒性作用，并诱导 OC 细胞凋亡。本综述从遗传改变、信号通路、转录因子和肿瘤微环境四个方面重点探讨了 OS 与 OC 发生发展的关系。此外，还总结和讨论了针对 OC 中异常 OS 的策略，以期为临床治疗提供新的思路。
