Shukla Prakriti, Gulwani Hanni V
Department of Pathology, Bhopal Memorial Hospital and Research Centre, Bhopal, Madhya Pradesh, India.
Indian J Pathol Microbiol. 2015 Oct-Dec;58(4):483-6. doi: 10.4103/0377-4929.168890.
Transformation of the urothelium to the intestinal type of epithelium is rare in the pelvis with very few cases reported in the literature. The present study reports extensive intestinal metaplasia of the pelvi-calyceal system without residual urothelium in a 35-years-old woman with a 2 years history of renal calculi. Right - sided Nephrectomy was undertaken. Immunohistochemistry of the metaplastic epithelium revealed positive expression of CK20, low Ki-67 index and negative expression of p53. In this patient long standing metaplastic changes did not progress to adenocarcinoma which indicates that extensive intestinal metaplasia is not always associated with malignancy.
肾盂黏膜上皮化生为肠型上皮在盆腔中很少见，文献报道的病例极少。本研究报告了一名35岁有2年肾结石病史的女性，其肾盂肾盏系统存在广泛的肠化生，无残余尿路上皮。遂进行了右侧肾切除术。化生上皮的免疫组织化学显示CK20呈阳性表达，Ki-67指数低，p53呈阴性表达。该患者长期的化生改变未进展为腺癌，这表明广泛的肠化生并不总是与恶性肿瘤相关。
