Sayar Hamide, Ersen Ayca, Kurtul Neslihan, Yazar Mehmet Fatih, Balakan Ozan
Department of Pathology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Indian J Pathol Microbiol. 2015 Oct-Dec;58(4):560-2. doi: 10.4103/0377-4929.168883.
Ependymomas commonly arise in the central nervous system. Extraneural presentation is quite rare. Herein, we describe a primary extraneural ependymoma in a young female. The mass was located in the right inguinal area. The cut surface of the 7.5 mm × 6.5 mm × 4.5 mm sized tumor was brownish-yellow in color. Histologically, it was hypercellular exhibiting pseudorosette or rosette formations and some papillary structures. Mitosis was counted as high as 10 per 10 high power fields. Neither necrosis nor vascular endothelial proliferation within the tumor was observed. Tumor cells showed strong glial fibrillary acidic protein immunoreactivity. On epithelial membrane antigen, intracytoplasmic dot-like immunostaining was observed. This is the first report presenting a primary extraneural anaplastic ependymoma arising in the inguinal subcutaneous region.
室管膜瘤通常发生于中枢神经系统。神经外表现相当罕见。在此，我们描述一例年轻女性的原发性神经外室管膜瘤。肿块位于右侧腹股沟区。该肿瘤大小为7.5毫米×6.5毫米×4.5毫米，切面呈棕黄色。组织学上，细胞丰富，呈现假菊形团或菊形团结构以及一些乳头状结构。有丝分裂计数高达每10个高倍视野10个。肿瘤内未观察到坏死或血管内皮细胞增生。肿瘤细胞显示胶质纤维酸性蛋白强免疫反应性。在上皮膜抗原方面，观察到胞浆内点状免疫染色。这是首例报道腹股沟皮下区域发生的原发性神经外间变性室管膜瘤。
