Harris R B, Martin R J
Department of Foods and Nutrition, University of Georgia, Athens 30602.
Proc Soc Exp Biol Med. 1989 May;191(1):82-9. doi: 10.3181/00379727-191-42893.
Reversible obesity provides a model for demonstration of weight regulation in mature animals. Changes in body composition and in vitro adipose and hepatic lipid synthesis and adipose lipolysis of rats recovering from enforced weight gain were examined to determine whether correction of weight was facilitated by metabolic changes independent of those resulting from hypophagia and negative energy balance. Female Sprague-Dawley rats (200 g) were divided into three groups. Controls ate ad libitum, tube-fed control rats were weight matched to controls. Two-hundred percent-fed rats were tube-fed twice control intake. After 26 days tube feeding stopped and a subgroup from each treatment was killed for determination of body composition and in vitro tissue metabolism. Further subgroups were examined 5, 10, 15, and 36 days later. At the end of overfeeding 200%-fed rats were hypophagic and had high rates of adipose and hepatic lipid synthesis, which soon returned to normal. Gross changes in body fat mass were corrected by hypophagia and increased adipose lipolysis. The remaining small excess in body fat appeared to be corrected by decreased basal and insulin-stimulated adipose fatty acid synthesis when food intake had returned to normal.
可逆性肥胖为研究成年动物体重调节提供了一个模型。对从强迫性体重增加中恢复的大鼠的身体组成、体外脂肪和肝脏脂质合成以及脂肪脂解的变化进行了研究，以确定体重的恢复是否由与因摄食减少和负能量平衡导致的代谢变化无关的代谢变化所促进。雌性Sprague-Dawley大鼠（200克）被分为三组。对照组自由进食，管饲对照大鼠的体重与对照组匹配。200%喂食组大鼠通过管饲给予两倍于对照组的摄入量。管饲26天后停止，每组各取一个亚组处死，用于测定身体组成和体外组织代谢。在之后的第5、10、15和36天对其他亚组进行检查。在过度喂养结束时，200%喂食组大鼠摄食减少，脂肪和肝脏脂质合成率较高，但很快恢复正常。身体脂肪量的总体变化通过摄食减少和脂肪脂解增加得到纠正。当食物摄入量恢复正常时，身体脂肪剩余的少量过量似乎通过基础和胰岛素刺激的脂肪脂肪酸合成减少得到纠正。
