来自三个非洲国家的金黄色葡萄球菌分离株中杀生物剂抗性决定因素的高流行率。
High Prevalence of Biocide Resistance Determinants in Staphylococcus aureus Isolates from Three African Countries.
作者信息
Conceição Teresa, Coelho Céline, de Lencastre Hermínia, Aires-de-Sousa Marta
机构信息
Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal.
Laboratory of Molecular Genetics, Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Universidade Nova de Lisboa (UNL), Oeiras, Portugal Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, New York, USA.
出版信息
Antimicrob Agents Chemother. 2015 Nov 9;60(1):678-81. doi: 10.1128/AAC.02140-15. Print 2016 Jan.
Abstract
We assessed the prevalence of six biocide resistance genes among 82 methicillin-resistant Staphylococcus aureus (MRSA) and 219 methicillin-susceptible S. aureus (MSSA) isolates from three African countries; the prevalence was very high for sepA (95.3%), mepA (89.4%), and norA (86.4%), intermediate for lmrS (60.8%) and qacAB (40.5%), and low for smr (3.7%). A significant association between biocide resistance genes and antibiotic resistance was observed, and a new cutoff MIC of ≥1 mg/liter for chlorhexidine nonsusceptibility was defined.
摘要
我们评估了来自三个非洲国家的82株耐甲氧西林金黄色葡萄球菌（MRSA）和219株甲氧西林敏感金黄色葡萄球菌（MSSA）分离株中六种抗微生物剂耐药基因的流行情况；sepA（95.3%）、mepA（89.4%）和norA（86.4%）的流行率非常高，lmrS（60.8%）和qacAB（40.5%）为中等，smr（3.7%）为低。观察到抗微生物剂耐药基因与抗生素耐药性之间存在显著关联，并确定了洗必泰不敏感的新临界最低抑菌浓度（MIC）≥1毫克/升。
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Clin Microbiol Infect. 2015 Sep;21(9):842.e1-842.e10. doi: 10.1016/j.cmi.2015.05.010. Epub 2015 May 21.
3
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J Antimicrob Chemother. 2015 Jul;70(7):2048-52. doi: 10.1093/jac/dkv056. Epub 2015 Mar 5.
4
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