Harris H, Hopkinson D A, Edwards Y H
Proc Natl Acad Sci U S A. 1977 Feb;74(2):698-701. doi: 10.1073/pnas.74.2.698.
The occurrence of polymorphism in a series of 87 different loci coding for enzyme structure in human populations has been related to the size and the number of subunits in the corresponding enzymes. Polymorphic and nonpolymorphic enzymes did not differ on average in subunit size. However, multimeric enzymes showed a significantly lower incidence of polymorphism than didmonomeric enzymes. A particularly low incidence of polymorphism was noted among multimeric enzymes in which interlocus molecular hybrids occur. The findings are discussed in terms of the "neutralist" and "selectionist" hypotheses of polymorphism.
在人类群体中，编码酶结构的一系列87个不同基因座上多态性的出现，已与相应酶的亚基大小和数量相关。多态性酶和非多态性酶在亚基大小上平均没有差异。然而，多聚体酶的多态性发生率明显低于单体酶。在发生基因座间分子杂交的多聚体酶中，多态性发生率特别低。根据多态性的“中立主义”和“选择主义”假说来讨论这些发现。
