人类肾脏丰富蛋白质中缺乏基因变异。
Lack of genic variation in the abundant proteins of human kidney.
作者信息
Smith S C, Racine R R, Langley C H
出版信息
Genetics. 1980 Dec;96(4):967-74. doi: 10.1093/genetics/96.4.967.
Abstract
Abundant proteins of 25 human kidneys were surveyed for genic variation by means of two-dimensional electrophoresis. Eighty-three (83) proteins were scored, and no genic variation was detected. This reduction in genic heterozygosity corroborates results determined with two-dimensional electrophoresis in mice and flies. These results suggest that previous estimates of electrophoretic variation may have been in error because of biased selection of loci.
摘要
通过二维电泳对25个人类肾脏的大量蛋白质进行基因变异检测。共对83种蛋白质进行了评分，未检测到基因变异。基因杂合性的这种降低证实了在小鼠和果蝇中通过二维电泳得出的结果。这些结果表明，由于基因座的选择存在偏差，以前对电泳变异的估计可能有误。
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