(16)氧气辐照增强 B6D2F1 小鼠的条件性恐惧记忆。
(16)Oxygen irradiation enhances cued fear memory in B6D2F1 mice.
机构信息
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA; Departments of Neurology and Radiation Medicine, Division of Neuroscience ONPRC, Oregon Health and Science University, Portland, OR 97239, USA.
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Life Sci Space Res (Amst). 2015 Nov;7:61-5. doi: 10.1016/j.lssr.2015.10.004. Epub 2015 Oct 22.
The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of (16)O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. (16)O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with (16)O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following (16)O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of (16)O ion exposure.
空间辐射环境包括可能影响认知表现的高能带电粒子。我们评估了（16）O 离子辐照对 C57BL/6J × DBA/2J F1（B6D2F1）小鼠认知表现的影响，辐照后一个月在俄勒冈健康与科学大学（波特兰，OR）进行，辐照源为布鲁克海文国家实验室（BNL，Upton，NY）。B6D2F1 小鼠的海马依赖的情境性恐惧记忆和海马独立的线索性恐惧记忆被测试。（16）O 离子暴露增强了线索性恐惧记忆。这种效应呈钟形剂量反应曲线。与假照射组或 1.6 Gy 照射组相比，接受 0.4 或 0.8 Gy（16）O 离子照射的小鼠的线索性恐惧记忆明显更强。与线索性恐惧记忆不同，在本研究中使用的剂量下，（16）O 离子照射后对情景性恐惧记忆没有影响。这些数据表明，杏仁核可能特别容易受到（16）O 离子暴露的影响。
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