Iancu Ovidiu Dan, Boutros Sydney Weber, Olsen Reid H J, Davis Matthew J, Stewart Blair, Eiwaz Massarra, Marzulla Tessa, Belknap John, Fallgren Christina M, Edmondson Elijah F, Weil Michael M, Raber Jacob
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States.
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Front Genet. 2018 Oct 9;9:404. doi: 10.3389/fgene.2018.00404. eCollection 2018.
Behavioral and cognitive traits have a genetic component even though contributions from individual genes and genomic loci are in many cases modest. Changes in the environment can alter genotype-phenotype relationships. Space travel, which includes exposure to ionizing radiation, constitutes environmental challenges and is expected to induce not only dramatic behavioral and cognitive changes but also has the potential to induce physical DNA damage. In this study, we utilized a genetically heterogeneous mouse model, dense genotype data, and shifting environmental challenges, including ionizing radiation exposure, to explore and quantify the size and stability of the genetic component of fear learning and memory-related measures. Exposure to ionizing radiation and other external stressors altered the genotype-phenotype correlations, although different behavioral and cognitive measures were affected to different extents. Utilizing an integrative genomic approach, we identified pathways and functional ontology categories associated with these behavioral and cognitive measures.
行为和认知特征具有遗传成分，尽管在许多情况下单个基因和基因组位点的贡献不大。环境变化可以改变基因型与表型的关系。太空旅行，包括暴露于电离辐射，构成了环境挑战，预计不仅会引起显著的行为和认知变化，还具有诱导物理DNA损伤的潜力。在本研究中，我们利用遗传异质性小鼠模型、密集的基因型数据以及包括电离辐射暴露在内的不断变化的环境挑战，来探索和量化恐惧学习和记忆相关指标的遗传成分的大小和稳定性。暴露于电离辐射和其他外部应激源会改变基因型与表型的相关性，尽管不同的行为和认知指标受到的影响程度不同。利用综合基因组学方法，我们确定了与这些行为和认知指标相关的途径和功能本体类别。
