Wak George, Williams John, Oduro Abraham, Maure Christine, Zuber Patrick L F, Black Steven
Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana.
Department of Essential Medicines and Health Products, World Health Organization, Geneva, Switzerland.
Clin Infect Dis. 2015 Nov 15;61 Suppl 5(Suppl 5):S489-92. doi: 10.1093/cid/civ625.
Group A meningococcal disease occurs in large epidemics within the meningitis belt of Africa that includes northern Ghana. Major epidemics in the meningitis belt have infection rates ranging from 100 to 800 per 100 000 population. In 2012, a group A meningococcal conjugate vaccine, PsA-TT (MenAfriVac), was introduced into the region in large campaigns.
We report here on the safety of this vaccine when used in pregnant women in the Navrongo region of Ghana.
Rates of events in 1730 immunized pregnant women and their infants were compared to the rates of the same events in pregnant women who did not receive the vaccine during the campaign and also to women who were pregnant in the prior year.
We found no evidence of any safety concerns when this vaccine was administered during pregnancy.
A群脑膜炎球菌病在包括加纳北部在内的非洲脑膜炎带大规模流行。脑膜炎带的主要流行中,感染率为每10万人口100至800例。2012年,一种A群脑膜炎球菌结合疫苗,PsA-TT(MenAfriVac),在大规模活动中引入该地区。
我们在此报告该疫苗在加纳纳瓦龙戈地区孕妇中使用时的安全性。
将1730名接种疫苗的孕妇及其婴儿的事件发生率与活动期间未接种疫苗的孕妇以及上一年怀孕的妇女中相同事件的发生率进行比较。
我们发现该疫苗在孕期接种时没有任何安全问题的证据。