a Vaccine Evaluation Center, BC Children's Hospital Research Institute, University of British Columbia , Vancouver , BC , Canada.
b Oxford Vaccine Group, Department of Paediatrics , University of Oxford, Children's Hospital , Oxford , UK.
Hum Vaccin Immunother. 2018 May 4;14(5):1188-1196. doi: 10.1080/21645515.2018.1445447. Epub 2018 Mar 21.
Invasive meningococcal disease causes meningitis and septicemia worldwide with highest rates of disease occurring in children <2 years of age, and in particular young infants. Vaccination during pregnancy has been a successful strategy for prevention of other infections in young infants, most notably tetanus, pertussis and influenza. However, few studies of meningococcal vaccines in pregnancy have been undertaken, and none include the most commonly used current vaccines to prevent disease by capsular groups A, B, C, W and Y. The limited data suggest that the older polysaccharide vaccines are immunogenic, but the impact on prevention of infant disease has not been measured. Further studies of MenB protein vaccines and MenA protein-polysaccharide conjugate vaccines in particular are needed if vaccination in pregnancy is to be utilized as an approach to prevention of meningococcal disease in young infants.
侵袭性脑膜炎球菌病在全球范围内引起脑膜炎和败血症，发病率最高的是<2 岁的儿童，尤其是婴幼儿。怀孕期间接种疫苗是预防婴幼儿其他感染（尤其是破伤风、百日咳和流感）的成功策略。然而，针对怀孕期间接种脑膜炎球菌疫苗的研究很少，并且都没有包括目前用于预防 A、B、C、W 和 Y 荚膜群疾病的最常用疫苗。有限的数据表明，较旧的多糖疫苗具有免疫原性，但对预防婴儿疾病的影响尚未得到衡量。如果要利用孕妇接种疫苗作为预防婴幼儿脑膜炎球菌病的一种方法，则特别需要进一步研究 MenB 蛋白疫苗和 MenA 蛋白-多糖结合疫苗。
