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暴露于冷等离子体处理的超高分子量聚乙烯磨损颗粒后的人间充质干细胞的纳米力学和表面特性。

Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles.

作者信息

Preedy Emily Callard, Perni Stefano, Prokopovich Polina

机构信息

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK; Department of Biological Engineering, MA Institute of Technology, Cambridge, MA, USA.

出版信息

Nanomedicine. 2016 Apr;12(3):723-734. doi: 10.1016/j.nano.2015.10.006. Epub 2015 Nov 10.

DOI:10.1016/j.nano.2015.10.006
PMID:26554392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4819529/
Abstract

UNLABELLED

Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre- and post-CAP treatment. The results indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 h of contact and the particle concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; while with longer CAP treatment this was not observed.

FROM THE CLINICAL EDITOR

Joint replacements are now common clinical practice. However, the use of ultra-high molecular weight polyethylene (UHMWPE) still poses a concern, due to the presence of wear debris. The authors here investigated the effects of wear debris after cold atmospheric plasma treatment on rat mesenchymal stem cells. The positive results provided new strategies in future design of joint replacement materials.

摘要

未标注

由于关节置换装置中使用的超高分子量聚乙烯（UHMWPE）产生的磨损碎屑会降低植入物的使用寿命，因此一直备受关注。冷大气等离子体（CAP）已被用于改善UHMWPE的磨损性能。我们的目的是通过原子力显微镜（AFM）研究大鼠间充质干细胞（rMSCs）在暴露于经CAP处理前后的UHMWPE磨损碎屑后的弹性和粘附特性。结果表明，暴露于磨损颗粒的间充质干细胞的细胞弹性和弹簧常数的主要变化发生在接触的前24小时，且颗粒浓度在0.5至50mg / l之间没有显著作用。对于处理7.5分钟的UHMWPE，随着磨损模拟的进行，经CAP处理的样品结果越来越接近未处理样品的结果；而在更长时间的CAP处理中未观察到这种情况。

来自临床编辑

关节置换现在是常见的临床实践。然而，由于磨损碎屑的存在，超高分子量聚乙烯（UHMWPE）的使用仍然令人担忧。作者在此研究了冷大气等离子体处理后的磨损碎屑对大鼠间充质干细胞的影响。积极的结果为未来关节置换材料的设计提供了新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/4dcacaae625b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/a40971fe6911/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/44a91298b557/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/77b36b0374b4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/a26222a847a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/409cdc9bb7ad/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/f95d1e2380d2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/4dcacaae625b/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/a40971fe6911/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/44a91298b557/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/77b36b0374b4/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/a26222a847a8/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/409cdc9bb7ad/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/f95d1e2380d2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea74/4819529/4dcacaae625b/gr8.jpg

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2
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Acta Biomater. 2015 Sep;23:38-51. doi: 10.1016/j.actbio.2015.05.016. Epub 2015 May 22.
3
Adhesive forces and surface properties of cold gas plasma treated UHMWPE.冷气体等离子体处理的超高分子量聚乙烯的粘附力和表面性质
基于聚β-氨基酯纳米载体的软骨药物递送系统
Nanomedicine. 2017 Feb;13(2):539-548. doi: 10.1016/j.nano.2016.10.001. Epub 2016 Oct 13.
Colloids Surf A Physicochem Eng Asp. 2014 Oct 20;460:83-89. doi: 10.1016/j.colsurfa.2014.03.052.
4
Interactions between mammalian cells and nano- or micro-sized wear particles: physico-chemical views against biological approaches.哺乳动物细胞与纳米或微米级磨损颗粒的相互作用：物理化学观点与生物学方法的对比。
Adv Colloid Interface Sci. 2014 Nov;213:36-47. doi: 10.1016/j.cis.2014.09.001. Epub 2014 Sep 16.
5
Quantification of clonal heterogeneity of mesenchymal progenitor cells in dental pulp and bone marrow.牙髓和骨髓中间充质祖细胞克隆异质性的定量分析。
Connect Tissue Res. 2014 Aug;55 Suppl 1:62-7. doi: 10.3109/03008207.2014.923859.
6
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7
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8
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