School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, UK; School of Engineering, Cardiff University, Cardiff, UK; Department of Biological Engineering, MA Institute of Technology, Cambridge, USA.
Adv Colloid Interface Sci. 2014 Nov;213:36-47. doi: 10.1016/j.cis.2014.09.001. Epub 2014 Sep 16.
Total joint arthroplasty (TJA) is a more and more frequent approach for the treatment of end-stage osteoarthritis in young and active adults; it successfully relieves joint pain and improves function significantly enhancing the health-related quality of life. Aseptic loosening and other wear-related complications are some of the most recurrent reasons for revision of TJA. This review focuses on current understanding of the biological reactions to prosthetic wear debris comparing in vivo and in vitro results. Mechanisms of interactions of various types of cells with metal, polymeric and ceramic wear particles are summarised. Alternative views based on multidisciplinary approaches are proposed to consider physico-chemical, surface parameters of wear particles (such as: particle size, geometry and charge) and material (particle chemical composition and its nature) with biological effects (cellular responses).
全关节置换术（TJA）是一种越来越常见的治疗年轻、活跃的晚期骨关节炎的方法；它能成功缓解关节疼痛，显著改善功能，极大地提高了与健康相关的生活质量。无菌性松动和其他与磨损相关的并发症是 TJA 翻修的最常见原因之一。本综述重点介绍了对假体磨损碎片的生物反应的现有理解，并比较了体内和体外的结果。总结了各种类型的细胞与金属、聚合物和陶瓷磨损颗粒相互作用的机制。基于多学科方法的替代观点被提出，以考虑磨损颗粒的物理化学特性、表面参数（如颗粒大小、形状和电荷）和材料（颗粒化学成分及其性质）与生物效应（细胞反应）之间的关系。
