Li Guo-Qiang, Zhang Yu-Bo, Wu Peng, Chen Neng-Hua, Wu Zhong-Nan, Yang Li, Qiu Rui-Xia, Wang Guo-Cai, Li Yao-Lan
International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine , Guangzhou 510006, People's Republic of China.
J Agric Food Chem. 2015 Dec 2;63(47):10257-62. doi: 10.1021/acs.jafc.5b04293. Epub 2015 Nov 19.
Seven new phloroglucinol derivatives (1-7) were isolated from the fruit tree Syzygium jambos together with four known triterpenoids (8-11) and two known flavones (12 and 13). According to the spectroscopic analyses (infrared, electrospray ionization mass spectrometry (ESIMS), high-resolution ESIMS, 1D and 2D nuclear magnetic resonance), the structures of compounds 1-7 were elucidated as jambone A (1), jambone B (2), jambone C (3), jambone D (4), jambone E (5), jambone F (6), and jambone G (7). All the isolates were determined for their cytotoxic activities on melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and compounds 10 and 11 showed potent activities. Moreover, compounds 1, 2, 4-7, 12, and 13 exhibited weak antioxidant activities under ferric-reducing antioxidant power and 2,2-diphenyl-1-picryhydrazyl radical-scavenging assays.
从蒲桃属植物蒲桃的果实中分离出7种新的间苯三酚衍生物（1 - 7），以及4种已知的三萜类化合物（8 - 11）和2种已知的黄酮类化合物（12和13）。根据光谱分析（红外光谱、电喷雾电离质谱（ESIMS）、高分辨率ESIMS、一维和二维核磁共振），化合物1 - 7的结构被鉴定为蒲桃素A（1）、蒲桃素B（2）、蒲桃素C（3）、蒲桃素D（4）、蒲桃素E（5）、蒲桃素F（6）和蒲桃素G（7）。通过3 -（4,5 - 二甲基噻唑 - 2 - 基）- 2,5 - 二苯基四氮唑溴盐法测定了所有分离物对黑色素瘤细胞的细胞毒性活性，化合物10和11表现出较强的活性。此外，在铁还原抗氧化能力和2,2 - 二苯基 - 1 - 苦基肼自由基清除试验中，化合物1、2、4 - 7、12和13表现出较弱的抗氧化活性。
