College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China.
College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Fitoterapia. 2018 Nov;131:141-145. doi: 10.1016/j.fitote.2018.10.010. Epub 2018 Oct 10.
Five new phloroglucinol derivatives (1-5) together with one known analogue (6) were isolated from the leaves of Syzygium austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A - E (1-5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR). Compounds 4-6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. This discovery of new phloroglucinols and their bioactivities provided a scientific basis for the application of S. austroyunnanense as an edible and medicinal plant.
从食用民间药物云南丁香叶中分离得到五个新的间苯三酚衍生物（1-5）和一个已知类似物（6）。新结构通过包括高分辨率电喷雾电离质谱（HRESIMS）和 1D 和 2D 核磁共振（NMR）在内的广泛光谱分析方法被阐明为 austroyunones A-E（1-5）。化合物 4-6 表现出明显的蛋白酪氨酸磷酸酶 1B（PTP1B）抑制活性。这些新间苯三酚类化合物的发现及其生物活性为云南丁香作为食用和药用植物的应用提供了科学依据。
