Saieva Calogero, Caini Saverio, Ceroti Marco, Fasanelli Francesca, Ricceri Fulvio, Agnoli Claudia, Grioni Sara, Mattiello Amalia, Santucci de Magistris Maria, Tumino Rosario, Martorana Caterina, Masala Giovanna
SC epidemiologia molecolare e nutrizionale, Istituto per lo studio e prevenzione oncologica (ISPO), Firenze.
Human Genetics Foundation (HuGeF), Torino.
Epidemiol Prev. 2015 Sep-Dec;39(5-6):345-9.
to evaluate the association between baseline and lifetime alcohol consumption and the risk of epithelial cancer (all types) in the Italian cohort of the European Prospective Investigation into Cancer and nutrition (EPIC) study.
prospective study carried out in a large Italian population.
detailed information on the consumption of alcoholic beverages at baseline and over lifetime collected at enrolment into the EPIC study (1993-1998) by standardised questionnaires for 44,477 healthy adults.
2,640 incident epithelial cancers identified during a mean follow-up of 11.4 years. Multivariate Cox proportional hazard models adjusted for several potential confounders were used to calculate hazard ratios (HR) and corresponding 95% confidence intervals (CI).
lifetime alcohol consumption (p for trend =0.005) was associated with epithelial cancer risk in the whole cohort. This effect was more evident in women (p =0.049) and in current smokers (p =0.012). Alcohol consumption at baseline was associated with the epithelial cancer risk in women (p for trend =0.01) and current smokers (p for trend =0.02). A significant interaction between alcohol consumption and smoke duration (p =0.015 for baseline; p =0.006 for lifetime) was identified.
in this large Italian population, alcohol consumption, particularly lifetime, is a significant risk factor for the development of epithelial cancers. This effect appears to be modulated by smoking habits.
在欧洲癌症与营养前瞻性调查（EPIC）研究的意大利队列中，评估基线及终生饮酒量与上皮癌（所有类型）风险之间的关联。
在一大群意大利人群中开展的前瞻性研究。
通过标准化问卷收集了44477名健康成年人在参与EPIC研究（1993 - 1998年）时的基线及终生酒精饮料消费详细信息。
在平均11.4年的随访期间确定的2640例上皮癌新发病例。使用针对多个潜在混杂因素进行调整的多变量Cox比例风险模型来计算风险比（HR）及相应的95%置信区间（CI）。
终生饮酒量（趋势p值 = 0.005）与整个队列中的上皮癌风险相关。这种效应在女性（p = 0.049）和当前吸烟者（p = 0.012）中更为明显。基线饮酒量与女性（趋势p值 = 0.01）和当前吸烟者（趋势p值 = 0.02）的上皮癌风险相关。确定了饮酒量与吸烟时长之间存在显著交互作用（基线时p = 0.015；终生时p = 0.006）。
在这个庞大的意大利人群中，饮酒，尤其是终生饮酒，是上皮癌发生的一个重要风险因素。这种效应似乎受吸烟习惯的调节。
