3%高渗盐水溶液与20%甘露醇治疗动脉瘤性蛛网膜下腔出血患者颅内高压的临床疗效比较
[Comparison clinical efficacy of 3% hypertonic saline solution with 20% mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage].
作者信息
Huang Xue-cai, Yang Ling-ling
机构信息
Department of Neurosurgery, Lishui Central Hospital, Lishui 323000, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jul;44(4):389-95. doi: 10.3785/j.issn.1008-9292.2015.07.07.
OBJECTIVE
To compare the efficacy of 3% hypertonic saline solution with 20% mannitol in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.
METHODS
An alternating treatment protocol was used to compare the efficacy of 160 mL 3% hypertonic saline solution (HSS) with 150 mL 20% mannitol for episodes of increased intracranial pressure (ICP) in patients with aneurysmal subarachnoid hemorrhage. The dependent variables were the extent and duration of reduction of increased ICP after each event.
RESULTS
Both 3% HSS and 20% mannitol rapidly decreased the ICP in patients with aneurysmal subarachnoid hemorrhage (P <0.01). No difference between two medications in the extent of duration of ICP and reduction of action (P >0.05).
CONCLUSION
3% HSS should be considered as the first-line osmotic drug in treatment of intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage.
目的
比较3%高渗盐水溶液与20%甘露醇治疗动脉瘤性蛛网膜下腔出血患者颅内高压的疗效。
方法
采用交替治疗方案，比较160 mL 3%高渗盐水溶液（HSS）与150 mL 20%甘露醇治疗动脉瘤性蛛网膜下腔出血患者颅内压（ICP）升高发作的疗效。因变量为每次事件后ICP升高降低的程度和持续时间。
结果
3% HSS和20%甘露醇均能迅速降低动脉瘤性蛛网膜下腔出血患者的ICP（P<0.01）。两种药物在ICP降低程度和作用持续时间方面无差异（P>0.05）。
结论
3% HSS应被视为治疗动脉瘤性蛛网膜下腔出血患者颅内高压的一线渗透性药物。
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