Seehus Corey R, Kaye Jonathan
Research Division of Immunology, Departments of Biomedical Sciences and Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Research Division of Immunology, Departments of Biomedical Sciences and Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA ; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Mediators Inflamm. 2015;2015:243868. doi: 10.1155/2015/243868. Epub 2015 Oct 18.
TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system. TOX is required for the development of CD4(+) T lineage cells in the thymus, including natural killer T and T regulatory cells, as well as development of natural killer cells and fetal lymphoid tissue inducer cells, the latter required for lymph node organogenesis. Recently, we have identified a broader role for TOX in the innate immune system, demonstrating that this nuclear protein is required for generation of bone marrow progenitors that have potential to give rise to all innate lymphoid cells. Innate lymphoid cells, classified according to transcription factor expression and cytokine secretion profiles, derive from common lymphoid progenitors in the bone marrow and require Notch signals for their development. We discuss here the role of TOX in specifying CLP toward an innate lymphoid cell fate and hypothesize a possible role for TOX in regulating Notch gene targets during innate lymphoid cell development.
TOX是HMG-box蛋白家族中一个进化保守的成员，对先天性和适应性免疫系统中各种细胞的发育至关重要。胸腺中CD4(+) T谱系细胞的发育需要TOX，包括自然杀伤T细胞和调节性T细胞，以及自然杀伤细胞和胎儿淋巴组织诱导细胞的发育，后者是淋巴结器官发生所必需的。最近，我们发现TOX在先天性免疫系统中具有更广泛的作用，表明这种核蛋白是产生具有产生所有先天性淋巴细胞潜力的骨髓祖细胞所必需的。先天性淋巴细胞根据转录因子表达和细胞因子分泌谱进行分类，来源于骨髓中的共同淋巴细胞祖细胞，其发育需要Notch信号。我们在此讨论TOX在将共同淋巴细胞祖细胞定向为先天性淋巴细胞命运过程中的作用，并推测TOX在先天性淋巴细胞发育过程中调节Notch基因靶点可能发挥的作用。
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