赫尔瓦乔格鲁重复性指数：一种评估视网膜神经纤维层测量中错位对光谱域光学相干断层扫描影响的新算法。
Helvacioglu reproducibility index: a new algorithm to evaluate the effects of misalignments on the measurements of retinal nerve fiber layer by spectral-domain OCT.
作者信息
Helvacioglu Firat, Uyar Osman Murat, Sencan Sadik, Tunc Zeki, Kapran Ziya
机构信息
Department of Ophthalmology, Maltepe University School of Medicine, Istanbul 38845, Turkey.
出版信息
Int J Ophthalmol. 2015 Oct 18;8(5):1008-12. doi: 10.3980/j.issn.2222-3959.2015.05.28. eCollection 2015.
AIM
To evaluate the effect of misalignment on the measurements of retinal nerve fiber layer (RNFL) by spectral-domain optical coherence tomography (OCT).
METHODS
A total of 42 eyes from 21 healthy young subjects underwent RNFL measurements with RTVue spectral-domain OCT (Optovue Inc., Fremont, California, USA). Two baseline measurements with perfectly aligned central circle to the borders of the optic nerve and four misaligned measurements which were misaligned towards to four quadrants were taken. The differences in RNFL between the baseline and misaligned measurements were analyzed with a new algorithm called Helvacioglu reproducibility index (HRI) which is designed to measure the reproducibility of the scans by evaluating the RNFL changes in the four main quadrants.
RESULTS
The average RNFL scores of the first two baseline measurements have good correlation (c=0.930) and good reproducibility scores (0.15±0.07). Superior misaligned measurements had significantly lower superior quadrant score and higher inferior quadrant score, similar nasal and little higher temporal scores (P1, P2<0.001, P3=0.553, P4=0.001). Inferior misaligned measurements had significantly higher superior quadrant score and lower inferior quadrant score with similar temporal and little lower nasal scores (P1, P2<0.001, P3=0.315, P4=0.016). Nasal misaligned measurements had significantly higher temporal quadrant score and lower nasal quadrant score with little lower superior and inferior scores (P1, P2, P4<0.001, P3=0.005). Temporal misaligned measurements had significantly higher nasal quadrant score and lower temporal quadrant score with similar superior and little higher inferior scores (P1, P2<0.001, P3=0.943, P4=0.001).
CONCLUSION
Good alignment of the central circle to the borders of optic nerve is crucial to have correct and repeatable RNFL measurements. Misalignment to a quadrant resulted in falsely low readings at that quadrant and falsely high readings at the opposite quadrant.
目的
评估视网膜神经纤维层（RNFL）测量中视轴不正对光谱域光学相干断层扫描（OCT）测量结果的影响。
方法
对21名健康年轻受试者的42只眼睛使用RTVue光谱域OCT（美国加利福尼亚州弗里蒙特市Optovue公司）进行RNFL测量。进行了两次视盘中心圆与视神经边界完全对齐的基线测量以及四次分别向四个象限视轴不正的测量。使用一种名为Helvacioglu重复性指数（HRI）的新算法分析基线测量和视轴不正测量之间RNFL的差异，该算法旨在通过评估四个主要象限中RNFL的变化来测量扫描的重复性。
结果
前两次基线测量的平均RNFL得分具有良好的相关性（c = 0.930）和良好的重复性得分（0.15±0.07）。上方视轴不正测量的上方象限得分显著降低，下方象限得分升高，鼻侧象限得分相似，颞侧象限得分略高（P1、P2<0.001，P3 = 0.553，P4 = 0.001）。下方视轴不正测量的上方象限得分显著升高，下方象限得分降低，颞侧象限得分相似，鼻侧象限得分略低（P1、P2<0.001，P3 = 0.315，P4 = 0.016）。鼻侧视轴不正测量的颞侧象限得分显著升高，鼻侧象限得分降低，上方和下方象限得分略低（P1、P2、P4<0.001，P3 = 0.005）。颞侧视轴不正测量的鼻侧象限得分显著升高，颞侧象限得分降低，上方象限得分相似，下方象限得分略高（P1、P2<0.001，P3 = 0.943，P4 = 0.001）。
结论
视盘中心圆与视神经边界良好对齐对于获得正确且可重复的RNFL测量结果至关重要。向一个象限视轴不正会导致该象限读数错误降低，而相对象限读数错误升高。
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