Department of Ophthalmology, The Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.
Ophthalmologica. 2013;229(1):38-42. doi: 10.1159/000337227. Epub 2012 Oct 12.
To measure the thickness of the retinal nerve fiber layer (RNFL) of patients with retinitis pigmentosa (RP) and that of normal controls by scanning laser polarimetry with enhanced corneal compensation (GDxECC) and RTVue-optical coherence tomography (OCT).
Fifty-two eyes of 26 patients were included. All patients underwent complete ophthalmological examinations and testing with GDxECC. Twenty-eight of 52 eyes of RP patients underwent RTVue-OCT measurements. A group of 50 eyes of 25 normal subjects (controls) was also included. GDxECC measured RNFL thickness in the peripapillary area in all subjects as well as temporal-superior-nasal-inferior-temporal (TSNIT) parameters, including TSNIT means, superior and inferior region means, TSNIT standard deviation (SD), inter-eye symmetry and nerve fiber indicator (NFI). RTVue-OCT measured the mean, superior, inferior, temporal and nasal quadrant RNFL thickness.
In RP patients and controls, TSNIT means by GDxECC were, respectively, 65.00 ± 7.35 and 55.32 ± 5.20. Mean superior quadrant thicknesses were 80.56 ± 10.93 and 69.54 ± 7.45. Mean inferior thicknesses were 80.58 ± 9.34 and 69.12 ± 7.78. SDs were 27.92 ± 5.21 and 28.23 ± 4.01. Inter-eye symmetries were 0.82 ± 0.17 and 0.87 ± 0.09. NFIs were 9.74 ± 8.73 and 16.81 ± 8.13. The differences between mean TSNIT, mean superior and mean inferior quadrant thicknesses and NFIs were statistically significant (p < 0.001). In RTVue-OCT measurements, the differences between mean, superior, inferior and temporal quadrant RNFL thicknesses were statistically significant (p = 0.0322, 0.0213, 0.0387, 0.0005).
The RNFL measured by GDxECC was significantly thicker in RP patients than in controls. RNFL thickness measured by RTVue-OCT was significantly greater in RP patients than in controls in the superior, inferior and temporal regions. This contribution provides information on RNFL thickness and discusses the mechanism underlying this phenomenon.
通过扫描激光偏振测量仪（GDxECC）和 RTVue 光学相干断层扫描（OCT）测量视网膜色素变性（RP）患者和正常对照者的视网膜神经纤维层（RNFL）厚度。
纳入 26 例患者的 52 只眼。所有患者均行全面眼科检查和 GDxECC 检查。28 只 RP 患者的眼行 RTVue-OCT 测量。另纳入 25 名正常受试者（对照组）的 50 只眼。GDxECC 测量所有受试者视盘周围区域的 RNFL 厚度以及颞上-鼻下-颞上-鼻下（TSNIT）参数，包括 TSNIT 平均值、上区和下区平均值、TSNIT 标准差（SD）、双眼对称性和神经纤维指数（NFI）。RTVue-OCT 测量平均、上、下、颞和鼻象限的 RNFL 厚度。
在 RP 患者和对照组中，GDxECC 的 TSNIT 平均值分别为 65.00 ± 7.35 和 55.32 ± 5.20。平均上象限厚度分别为 80.56 ± 10.93 和 69.54 ± 7.45。平均下象限厚度分别为 80.58 ± 9.34 和 69.12 ± 7.78。SD 分别为 27.92 ± 5.21 和 28.23 ± 4.01。双眼对称性分别为 0.82 ± 0.17 和 0.87 ± 0.09。NFI 分别为 9.74 ± 8.73 和 16.81 ± 8.13。TSNIT 平均值、上象限和下象限平均厚度和 NFI 的差异均具有统计学意义（p < 0.001）。在 RTVue-OCT 测量中，平均、上、下和颞象限 RNFL 厚度的差异具有统计学意义（p = 0.0322、0.0213、0.0387、0.0005）。
GDxECC 测量的 RP 患者的 RNFL 明显比对照组厚。RTVue-OCT 测量的 RP 患者的上、下和颞区的 RNFL 厚度明显大于对照组。本研究为 RNFL 厚度提供了信息，并探讨了这种现象的发生机制。
