Wang Juan, Jin Ping, Wang Wen-Hui, He Mei, Zhang Zi-Teng, Liu Yu
Department of Clinical Laboratory, Renmin Hospital, Hubei University of Medicine, China.
J Toxicol Sci. 2015 Dec;40(6):711-8. doi: 10.2131/jts.40.711.
Many studies have investigated the association between the A118G polymorphism in the μ-opioid receptor gene and smoking behaviors, but the results remain controversial. This meta-analysis aimed to derive a more reliable estimate of the effect of the A118G polymorphism on smoking behaviors. We systematically searched the PubMed/Medline, Embase and Web of Science databases for eligible articles published up to October 23, 2014. A total of six studies were selected. Odds ratios (ORs) as well as their corresponding 95% confidence intervals (CIs) were used to estimate the association between A118G polymorphism and smoking behaviors in four genetic models. Heterogeneity analysis and publication bias were also performed. Subgroup analysis was conducted according to different ethnicities. The meta-analysis was performed using either a fixed- or random-effects model as deemed appropriate. In the result of the meta-analysis, a significant association was detected in the dominant model in the Caucasian subgroup (OR = 3.26, 95% CI = 2.65-4.05). This result indicated that Caucasians carrying the G allele (AG + GG) of the A118G polymorphism in the μ-opioid receptor gene were more likely to be addicted to smoking compared with those with the AA homozygote. However, no significant association was found in other genetic models.
许多研究调查了μ-阿片受体基因中A118G多态性与吸烟行为之间的关联，但结果仍存在争议。这项荟萃分析旨在更可靠地估计A118G多态性对吸烟行为的影响。我们系统地检索了PubMed/Medline、Embase和Web of Science数据库，以查找截至2014年10月23日发表的符合条件的文章。共选择了六项研究。比值比（OR）及其相应的95%置信区间（CI）用于估计四种遗传模型中A118G多态性与吸烟行为之间的关联。还进行了异质性分析和发表偏倚分析。根据不同种族进行亚组分析。根据情况使用固定效应模型或随机效应模型进行荟萃分析。在荟萃分析结果中，在白种人亚组的显性模型中检测到显著关联（OR = 3.26，95% CI = 2.65 - 4.05）。该结果表明，与AA纯合子相比，携带μ-阿片受体基因中A118G多态性G等位基因（AG + GG）的白种人更易吸烟成瘾。然而，在其他遗传模型中未发现显著关联。
