阿片受体μ1（OPRM1）A118G多态性（rs1799971）与尼古丁依赖的关联。

Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence.

作者信息

Kong Xiangyi, Deng Hao, Alston Theodore, Kong Yanguo, Wang Jingping

机构信息

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Dongcheng District, Beijing 100730, P. R. China.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02114-3117, United States of America.

出版信息

Oncotarget. 2017 Sep 15;8(48):84329-84337. doi: 10.18632/oncotarget.20939. eCollection 2017 Oct 13.

DOI:10.18632/oncotarget.20939

PMID:29137427

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5663599/

Abstract

BACKGROUND AND OBJECT

Whether opioid-receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) is associated with nicotine dependence is controversial. We analyzed the combined results from published studies of this possibility.

METHODS

Literature reviews were performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, Chinese National Science Infrastructure (CNKI), PubMed, Embase and Google Scholar database searches using MeSH terms were conducted to find all relevant researches up to October 2016. Odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated in allele, homozygote, heterozygote, dominant and recessive models. Ethnicity-specific subgroup meta-analysis, heterogeneity, sensitivity analysis and publication bias were considered.

RESULTS

Seven eligible studies with 3313 patients were included. The ORs in the five genetic models mentioned above were 1.000 (95% CI: 0.906, 1.104; p = 0.999), 1.032 (95% CI: 0.771, 1.381; p = 0.834), 0.963 (95% CI: 0.799, 1.162; p = 0.696), 1.006 (95% CI: 0.916, 1.104; p = 0.907), 0.967 (95% CI: 0.715, 1.309; p = 0.830), respectively. Only in dominant model is the association significant. Upon ethnicity-specific subgroup analysis, there is no statistical significance.

CONCLUSION

OPRM1-A118G polymorphism (A>G) is not associated with nicotine dependence.

摘要

背景与目的

阿片受体μ1（OPRM1）A118G多态性（rs1799971）是否与尼古丁依赖相关存在争议。我们分析了已发表研究中关于这种可能性的综合结果。

方法

根据系统评价与Meta分析的首选报告项目（PRISMA）指南进行文献综述。使用医学主题词（MeSH）在Web of Science、中国国家科学基础设施（CNKI）、PubMed、Embase和谷歌学术数据库中进行检索，以查找截至2016年10月的所有相关研究。在等位基因、纯合子、杂合子、显性和隐性模型中计算比值比（OR）及其95%置信区间（95%CI）。考虑了种族特异性亚组Meta分析、异质性、敏感性分析和发表偏倚。

结果

纳入了7项符合条件的研究，共3313例患者。上述5种遗传模型中的OR分别为1.000（95%CI：0.906，1.104；p = 0.999）、1.032（95%CI：0.771，1.381；p = 0.834）、0.963（95%CI：0.799，1.162；p = 0.696）、1.006（95%CI：0.916，1.104；p = 0.907）、0.967（95%CI：0.715，1.309；p = 0.830）。仅在显性模型中该关联具有统计学意义。在种族特异性亚组分析中，无统计学意义。