Takeda Shuso, Hirota Rena, Teradaira Sari, Takeda-Imoto Masumi, Watanabe Kazuhito, Toda Akihisa, Aramaki Hironori
Department of Molecular Biology, Daiichi University of Pharmacy.
J Toxicol Sci. 2015 Dec;40(6):739-43. doi: 10.2131/jts.40.739.
The biological activities of cannabidiol (CBD), a major non-psychotropic constituent of the fiber-type cannabis plant, have been examined in detail (e.g., CBD modulation of body weight in mice and rats). However, few studies have investigated the biological activities of cannabidiol-2',6'-dimethyl ether (CBDD), a dimethyl ether derivative of the parent CBD. We herein focused on the effects of CBDD on body weight changes in mice, and demonstrated that it stimulated body weight gain in apolipoprotein E (ApoE)-deficient BALB/c. KOR/Stm Slc-Apoe(shl) mice, especially between 10 and 20 weeks of age.
大麻二酚（CBD）是纤维型大麻植物的一种主要非精神活性成分，其生物活性已得到详细研究（例如，CBD对小鼠和大鼠体重的调节作用）。然而，很少有研究调查大麻二酚-2',6'-二甲醚（CBDD）这种母体CBD的二甲醚衍生物的生物活性。我们在此重点研究了CBDD对小鼠体重变化的影响，并证明它能刺激载脂蛋白E（ApoE）缺陷的BALB/c.KOR/Stm Slc-Apoe(shl)小鼠体重增加，尤其是在10至20周龄之间。
