Department of Animal Physiology, University of Gdansk, 24 Kladki St., 80-822 Gdansk, Poland.
Neurosci Lett. 2011 Feb 18;490(1):82-4. doi: 10.1016/j.neulet.2010.12.031. Epub 2010 Dec 21.
Cannabidiol (CBD) is a major non-psychotropic constituent of Cannabis sativa, with well recognized therapeutic potential. Considering the importance of the endogenous cannabinoid system to the regulation of food intake and energy balance we studied the effects of repeated CBD administration on body weight gains in rats. Male Wistar rats (260 ± 20 g at start of study) received intraperitoneal injections of CBD at doses of 2.5 and 5mg/kg/day for 14 consecutive days and body weight gains were monitored. Both doses of CBD produced significant decrease in body weight gain, with the effect produced by 5mg/kg being more pronounced. The CB2 receptor selective antagonist, AM630, blocked the decrease in body weight gain. AM630 alone did not affect body weight gain. The results suggest that CBD has the ability to alter body weight gain, possibly via the CB2 receptor. CB2 receptors may play a role in the regulation of body weight and the effects of CB2 specific ligands should be further investigated in studies of body weight regulation.
大麻二酚（CBD）是大麻的主要非精神活性成分，具有公认的治疗潜力。鉴于内源性大麻素系统对食物摄入和能量平衡的调节作用，我们研究了重复给予 CBD 对大鼠体重增加的影响。雄性 Wistar 大鼠（研究开始时体重为 260±20g）连续 14 天每天接受腹腔注射 CBD 2.5 和 5mg/kg，监测体重增加。两种剂量的 CBD 均显著降低体重增加，5mg/kg 产生的效果更为明显。CB2 受体选择性拮抗剂 AM630 阻断了体重增加的减少。AM630 本身不会影响体重增加。结果表明，CBD 具有改变体重增加的能力，可能通过 CB2 受体。CB2 受体可能在体重调节中发挥作用，应进一步研究 CB2 特异性配体对体重调节的影响。
