对无症状患者进行血液和尿液常规筛查以检测对抗惊厥药物的严重反应，其价值存疑。
Routine screening of blood and urine for severe reactions to anticonvulsant drugs in asymptomatic patients is of doubtful value.
作者信息
Camfield P, Camfield C, Dooley J, Farrell K, Humphreys P, Langevin P
机构信息
Izaak Walton Killam Hospital for Children, Halifax.
出版信息
CMAJ. 1989 Jun 1;140(11):1303-5.
Severe or fatal reactions to anticonvulsant agents are fortunately rare. We examined the value of routine screening of blood and urine to detect early signs of such reactions in asymptomatic patients. The basic assumptions of this type of screening program have been faulty or unproven, and the results of studies, although not definitive, have not supported the value of such programs. Our recommendations, approved by the Canadian Association for Child Neurology, suggest that asymptomatic patients not undergo routine screening of blood and urine but, rather, be informed of the early symptoms of severe toxic reactions and be asked to report them immediately to a physician.
幸运的是，对抗惊厥药物的严重或致命反应很少见。我们研究了对无症状患者进行血液和尿液常规筛查以检测此类反应早期迹象的价值。这类筛查项目的基本假设存在错误或未经证实，并且研究结果虽然不明确，但并不支持此类项目的价值。我们的建议经加拿大儿童神经病学协会批准，建议无症状患者不要进行血液和尿液常规筛查，而是应被告知严重毒性反应的早期症状，并被要求立即向医生报告这些症状。
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