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丙酸倍氯米松氢氟烷烃用于治疗过敏性鼻炎。

Beclomethasone dipropionate hydrofluoroalkane for the treatment of allergic rhinitis.

作者信息

Ferrante Giuliana, Montalbano Laura, Cilluffo Giovanna, Malizia Velia, Marchese Donatella, La Grutta Stefania

机构信息

a Department of Science for Health Promotion and Mother and Child Care , University of Palermo , Palermo , Italy.

b National Research Council CNR , Institute of Biomedicine and Molecular Immunology IBIM , Palermo , Italy.

出版信息

Expert Rev Clin Immunol. 2016;12(3):279-88. doi: 10.1586/1744666X.2016.1118347. Epub 2015 Dec 11.

Abstract

Allergic rhinitis (AR) is a common respiratory disease, and its prevalence is increasing all over the world, both in adults and in children. Patients experience symptoms that may negatively impact on physical, social and psychological well-being. Hence, if left untreated, allergic rhinitis may significantly affect quality of life. Under current guidelines, intranasal corticosteroids are considered the most effective drugs and they are recommended as first-line therapy. Among the several corticosteroid intranasal sprays available, beclomethasone dipropionate is one of the most prescribed. Recently, new intranasal hydrofluoroalkane-propelled formulations with little or no impact on the ozone layer have been developed for the treatment of AR. The use of these devices might improve patients' adherence to treatment, avoiding some of the most common side effects associated with aqueous formulations. This review provides the most recent evidence for the efficacy and safety of beclomethasone dipropionate hydrofluoroalkane nasal aerosol in the treatment of allergic rhinitis.

摘要

变应性鼻炎(AR)是一种常见的呼吸道疾病,其患病率在全球范围内,无论成人还是儿童,都呈上升趋势。患者会出现一些可能对身体、社交和心理健康产生负面影响的症状。因此,如果不进行治疗,变应性鼻炎可能会显著影响生活质量。根据现行指南,鼻用糖皮质激素被认为是最有效的药物,并被推荐作为一线治疗药物。在现有的几种鼻用糖皮质激素喷雾剂中,二丙酸倍氯米松是处方量最多的药物之一。最近,已开发出对臭氧层影响很小或没有影响的新型氢氟烷烃推进的鼻用制剂用于治疗AR。使用这些装置可能会提高患者对治疗的依从性,避免一些与水性制剂相关的最常见副作用。本综述提供了二丙酸倍氯米松氢氟烷烃鼻气雾剂治疗变应性鼻炎有效性和安全性的最新证据。

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