微小RNA-34家族及其在心血管疾病中的作用。
MicroRNA-34 Family and Its Role in Cardiovascular Disease.
作者信息
Li Na, Wang Kun, Li Pei-Feng
机构信息
Center for Developmental Cardiology, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao 266021, China.
出版信息
Crit Rev Eukaryot Gene Expr. 2015;25(4):293-7. doi: 10.1615/critreveukaryotgeneexpr.2015015396.
MicroRNAs (miRNAs) have been considered important regulators in both physiological and disease contexts. Among all miRNAs, the miR-34 family (miR-34a, -34b, -34c), which has been well characterized as a tumor suppressor, displays diverse functions in noncancerous diseases. MiR-34 levels are relatively low in the cardiovascular system, but recently they have been reported to function in cardiovascular disorders by regulating apoptosis, telomere attrition, DNA damage, and inflammatory response. In this review, we mainly summarize their roles in cardiac senescence and ischemic diseases.
微小RNA（miRNA）在生理和疾病环境中均被视为重要的调节因子。在所有miRNA中，已被充分表征为肿瘤抑制因子的miR-34家族（miR-34a、-34b、-34c）在非癌性疾病中发挥着多种功能。miR-34在心血管系统中的水平相对较低，但最近有报道称它们通过调节细胞凋亡、端粒损耗、DNA损伤和炎症反应在心血管疾病中发挥作用。在本综述中，我们主要总结它们在心脏衰老和缺血性疾病中的作用。
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