分枝杆菌主要易化子超家族对结核病新防治措施的意义

Implications of Mycobacterium Major Facilitator Superfamily for Novel Measures against Tuberculosis.

作者信息

Wang Rui, Zhang Zhen, Xie Longxiang, Xie Jianping

机构信息

Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Three Gorges Eco-environment and Bioresources, Key Laboratory Ministry of Education Eco-Environment of the Three Gorges Reservoir Region, School of Life Sciences, Southwest Univ.

Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.

出版信息

Crit Rev Eukaryot Gene Expr. 2015;25(4):315-21. doi: 10.1615/critreveukaryotgeneexpr.2015014371.

DOI:10.1615/critreveukaryotgeneexpr.2015014371

PMID:26559092

Abstract

Major facilitator superfamily (MFS) is an important secondary membrane transport protein superfamily conserved from prokaryotes to eukaryotes. The MFS proteins are widespread among bacteria and are responsible for the transfer of substrates. Pathogenic Mycobacterium MFS transporters, their distribution, function, phylogeny, and predicted crystal structures were studied to better understand the function of MFS and to discover specific inhibitors of MFS for better tuberculosis control.

摘要

主要易化子超家族（MFS）是一种重要的二级膜转运蛋白超家族，从原核生物到真核生物都保守存在。MFS蛋白广泛分布于细菌中，负责底物的转运。对致病性分枝杆菌的MFS转运蛋白、它们的分布、功能、系统发育及预测的晶体结构进行了研究，以更好地理解MFS的功能，并发现MFS的特异性抑制剂，从而更好地控制结核病。