新型α-葡萄糖苷酶抑制剂4-O-α-D-吡喃葡萄糖基吗啉及其N-取代衍生物的合成与α-葡萄糖苷酶抑制活性
Synthesis and alpha-glucosidase-inhibiting activity of a new alpha-glucosidase inhibitor, 4-O-alpha-D-glucopyranosylmoranoline and its N-substituted derivatives.
作者信息
Yoshikuni Y, Ezure Y, Seto T, Mori K, Watanabe M, Enomoto H
出版信息
Chem Pharm Bull (Tokyo). 1989 Jan;37(1):106-9. doi: 10.1248/cpb.37.106.
PMID:2655949
Abstract
Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.
摘要
已合成了4-O-α-D-吡喃葡萄糖基吗啉的各种N-取代衍生物，并测定了它们对兔蔗糖酶和麦芽糖酶的抑制活性，以及它们对蔗糖负荷大鼠餐后高血糖的影响。4-O-α-D-吡喃葡萄糖基吗啉在淀粉负荷犬中也显示出强效的降血糖活性。
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