鞘氨醇-1-磷酸（S1P）在兔蛛网膜下腔出血后脑血管痉挛中的表达
Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits.
作者信息
Tang Hua, Zhao Donggang, Chen Shaojun, Fang Ming, Wang Feifan, Cui Ying, Tang Na, Chen Qianxue
机构信息
Department of Neurosurgery, Wuhan University, Hubei Province, P.R.C, China.
Department of Neurosurgery, Renmin Hospital, Three Gorges University, Hubei Province, P.R.C., China.
出版信息
Acta Cir Bras. 2015 Oct;30(10):654-9. doi: 10.1590/S0102-865020150100000001.
PURPOSE
To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).
METHODS
The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.
RESULTS
The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.
CONCLUSION
Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.
目的
探讨1-磷酸鞘氨醇（S1P）表达与蛛网膜下腔出血（SAH）之间的关系。
方法
采用SAH“双出血”兔模型的基底动脉来研究S1P表达与SAH的关系。在第3、5、7、9天测量各种症状，包括血凝块、基底动脉横截面积和S1P磷酸酶表达。
结果
兔蛛网膜下腔出血后脑血管痉挛中S1P表达增强。并且在第3、5、7、9天S1P表达与基底动脉横截面积变化一致。
结论
脑动脉中1-磷酸鞘氨醇表达可能是蛛网膜下腔出血后脑血管痉挛发生发展的一个新指标，并为SAH提供一种新的治疗方法。
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