Yang Bosco Seong Kyu, Blackburn Spiros L, Lorenzi Philip L, Choi Huimahn A, Gusdon Aaron M
Department of Neurosurgery, McGovern School of Medicine, University of Texas Health Science Center, and Memorial Hermann Hospital at the Texas Medical Center, United States.
Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center (MDACC), United States.
Neurotherapeutics. 2025 Jan;22(1):e00504. doi: 10.1016/j.neurot.2024.e00504. Epub 2024 Dec 19.
Aneurysmal subarachnoid hemorrhage (aSAH) results in a complex systemic response that is critical to the pathophysiology of late complications and has important effects on outcomes. Omics techniques have expanded our investigational scope and depth into this phenomenon. In particular, metabolomics-the study of small molecules, such as blood products, carbohydrates, amino acids, and lipids-can provide a snapshot of dynamic subcellular processes and thus broaden our understanding of molecular-level pathologic changes that lead to the systemic response after aSAH. Lipids are especially important due to their abundance in the circulating blood and numerous physiological roles. They are comprised of a wide variety of subspecies and are critical for cellular energy metabolism, the integrity of the blood-brain barrier, the formation of cell membranes, and intercellular signaling including neuroinflammation and ferroptosis. In this review, metabolomic and lipidomic pathways associated with aSAH are summarized, centering on key metabolites from each metabolomic domain.
动脉瘤性蛛网膜下腔出血（aSAH）会引发复杂的全身反应，这对晚期并发症的病理生理学至关重要，并对预后产生重要影响。组学技术拓展了我们对这一现象的研究范围和深度。特别是代谢组学——对血液制品、碳水化合物、氨基酸和脂质等小分子的研究——可以提供动态亚细胞过程的快照，从而拓宽我们对导致aSAH后全身反应的分子水平病理变化的理解。脂质尤为重要，因为它们在循环血液中含量丰富且具有众多生理作用。它们由各种各样的亚类组成，对细胞能量代谢、血脑屏障的完整性、细胞膜的形成以及包括神经炎症和铁死亡在内的细胞间信号传导至关重要。在本综述中，总结了与aSAH相关的代谢组学和脂质组学途径，重点关注每个代谢组学领域的关键代谢物。
